Moving Beyond Boundaries: Utilization of Longitudinal Exposure –Response Model for Bounded Outcome Score to Inform Decision Making in the Accelerated Drug Development Paradigm

ConclusionThe CBO modeling approach and simulation supported the single pivotal trial strategy and guided dose selection in the accelerated drug development program of ritlecitinib, which can be applied to many indications where efficacy is measured on a bounded scale.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research