Low-frequency stimulation in the zona incerta attenuates seizure via driving GABAergic neuronal activity

CONCLUSION: Our results demonstrate that low-frequency DBS in the ZI attenuates seizure via driving GABAergic neuronal activity. This suggests that the ZI represents a potential DBS target for treating both hippocampal and cortical seizure through the activation of GABAergic neurons, thereby holding therapeutic significance for seizure treatment.PMID:38290566 | DOI:10.1016/j.nbd.2024.106424

Source: Neurobiology of Disease - January 30, 2024 Category: Neurology Authors: Mengdi Zhang Lin Yang Zhongxia Li Fan Fei Yuan Zhou Dongxiao Jiang Yuyi Zheng Hui Cheng Yu Wang Cenglin Xu Jiajia Fang Shuang Wang Zhong Chen Yi Wang Source Type: research