Enoxaparin for VTE thromboprophylaxis during inpatient rehabilitation care: assessment of the standard fixed dosing regimen

CONCLUSIONS: Our study confirmed that a one-size-fits-all approach for venous thromboembolism (VTE) prophylaxis may be inadequate for rehabilitation patient populations. The efficacy of fixed-dose enoxaparin prophylaxis is limited and may be influenced by renal function and weight. This study suggests that anti-Xa studies and prophylactic enoxaparin dose adjustments should be considered in certain patients, such as those who are underweight, overweight and or have suboptimal renal function.TRIAL REGISTRATION: No. NCT103593291, registered August 2018.PMID:38200581 | PMC:PMC10782744 | DOI:10.1186/s40360-023-00728-0
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Source Type: research