The European Lead Factory: Results from a decade of collaborative, public-private, drug discovery programs

Drug Discov Today. 2024 Jan 18;29(3):103886. doi: 10.1016/j.drudis.2024.103886. Online ahead of print.ABSTRACTThe European Lead Factory (ELF) is a consortium of universities and small and medium-sized enterprises (SMEs) dedicated to drug discovery, and the pharmaceutical industry. This unprecedented consortium provides high-throughput screening, triage, and hit validation, including to non-consortium members. The ELF library was created through a novel compound-sharing model between nine pharmaceutical companies and expanded through library synthesis by chemistry-specialized SMEs. The library has been screened against ∼270 different targets and 15 phenotypic assays, and hits have been developed to form the basis of patents and spin-off companies. Here, we review the outcome of screening campaigns of the ELF, including the performance and physicochemical properties of the library, identification of possible frequent hitter compounds, and the effectiveness of the compound-sharing model.PMID:38244673 | DOI:10.1016/j.drudis.2024.103886

Source: Drug Discovery Today - January 20, 2024 Category: Drugs & Pharmacology Authors: Herman van Vlijmen Andrew D Pannifer Phil Cochrane Daniel Basting Volkhart M Li Ola Engkvist Jean-Yves Ortholand Markus Wagener James Duffy Dirk Finsinger Jeremy Davis Steven P van Helden Jon S B de Vlieger European Lead Factory Consortium Source Type: research