Cancers, Vol. 16, Pages 791: Male Fertility and Fatherhood in Chronic Myeloid Leukemia: Current Understanding and Future Perspectives

Cancers, Vol. 16, Pages 791: Male Fertility and Fatherhood in Chronic Myeloid Leukemia: Current Understanding and Future Perspectives Cancers doi: 10.3390/cancers16040791 Authors: Ahmed Adel Elsabagh Maria Benkhadra Ibrahim Elmakaty Abdelrahman Elsayed Basant Elsayed Mohamed Elmarasi Mohammad Abutineh Nabeel Mohammad Qasem Elrazi Ali Mohamed Yassin Chronic myeloid leukemia (CML), while traditionally a disease of the elderly, has recently risen in incidence among younger patients. Hence, fertility concerns have emerged considering the disease process and treatments, especially with the current scarce and conflicting recommendations. This review explores the impact of CML treatments including the first-line tyrosine kinase inhibitors (TKIs) and other treatments on male fertility in chronic myeloid leukemia (CML) patients. The aim of this review was to compile the available evidence on male fertility to ultimately tailor treatment plans for male CML patients for whom fertility and future chances for conception pose a concern. The data available on the conventional and newer TKIs to address fertility concerns were reviewed, particularly the potential long- and short-term effects. Also, the possible side effects on subsequent generations were a crucial focus point of this review to reach a more comprehensive CML management approach. We found and compared the evidence on TKIs approved to treat CML. We also reported the effects of hydroxyurea, interferon, a...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research