An alternative method to establish an early acute ocular toxoplasmosis model for experimental tests

ConclusionInfection of C57BL6 mice via intraperitoneal with 104 tachyzoites of the ME49-GFP strain from cell culture is a suitable model for acute ocular toxoplasmosis. This model has great reproducibility in establishing the ocular lesion since day 5 post-infection. This model can be suitable for experimental tests of chemotherapy and the investigation of the role of the immune response on the development of uveitis.
Source: International Ophthalmology - Category: Opthalmology Source Type: research