Association of Red Blood Cell and Platelet Parameters with Metabolic Syndrome: A Systematic Review and Meta-Analysis of 170,000 Patients
Horm Metab Res DOI: 10.1055/a-2241-5361This systematic review and meta-analysis aim to establish associations between
metabolic syndrome (MetS) and erythrocyte and platelet markers, contributing to
improved diagnostic tests for identifying individuals at risk. Observational
studies and Randomized Controlled Trials (RCTs) were included. The standardized
mean difference (SMD) and 95% confidence intervals (CI) of erythrocyte
and platelet markers between individuals with and without MetS were used as
effect size (inverse variance model). Methodological quality assessment was
conducted using the Newcastle-Ottawa scale (NOS) for observational studies and
the Cochrane Risk of Bias tool 2.0 for RCTs. The analysis included 51 articles.
Compared to controls, individuals with MetS exhibited significantly higher
concentrations of mean red blood cell count [Standardized Mean Difference
(95% CI): 0.15 (0.13−0.18); p<0.00001], hemoglobin [0.24
(0.18−0.31); p<0.00001], blood platelet count [5.49
(2.78–8.20); p<0.0001], and red blood cell distribution width
[(0.55 (0.05–1.04); p=0.03]. Regarding mean platelet volume
[0.16 (– 0.03 to 0.35); p=0.10] and
platelet-to-lymphocyte ratio (PLR) [7.48 (–2.85–17.81);
p=0.16], a non-significant difference was observed in patients with
MetS. There was no...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Mahmood, Aysal Samad, Saba Haider, Hoorain Hassan, Wardah Mushtaq, Rabeea Perwaiz, Aimen Ali, Abraish Azharuddin, Muhammad Tags: Original Article: Endocrine Care Source Type: research