Association of peritumoral region features assessed on breast MRI and prognosis of breast cancer: a systematic review and meta-analysis

ConclusionThe presence of peritumoral edema and adjacent vessel signs, higher peritumor-tumor ADC ratio, and peritumoral ADCmean were significantly correlated with poor prognosis of breast cancer.Clinical relevance statementMRI features of the peritumoral region can be used as a non-invasive index for the prognostic evaluation of invasive breast cancer.Key Points• Peritumoral edema was positively associated with non-luminal breast cancer, high expression of the Ki-67 index, high histological grade, lymph node metastasis, negative expression of HR, and lymphovascular invasion.• The adjacent vessel sign was associated with greater odds of breast cancers with poor prognosis.• Breast cancers with poor prognosis had higher peritumor-tumor ADC ratio and peritumoral ADCmean.
Source: European Radiology - Category: Radiology Source Type: research