A meta-analysis comparing the diagnostic performance of computed tomography-derived fractional flow reserve and coronary computed tomography angiography at different levels of coronary artery calcium score

ConclusionsCT-FFR demonstrates superior diagnostic performance in low CACS groups (CACS  <  400) than CCTA in detecting hemodynamic stenoses in patients with coronary artery disease (CAD).Clinical relevance statementComputed tomography-derived fractional flow reserve might be utilized to determine the necessity of invasive coronary angiography in coronary artery disease patients with coronary artery calcium score  <  400.Key Points•There is a lack of meta-analysis comparing the diagnostic performance of computed tomography-derived fractional flow reserve and coronary computed tomography angiography at different levels of calcification.• Computed tomography-derived fractional flow reserve only has a better diagnostic performance than coronary computed tomography angiography with low amounts of coronary calcium.• For the low coronary artery calcium score group, computed tomography-derived fractional flow reserve might be a good non-invasive method to detect hemodynamic stenoses in coronary artery disease patients.
Source: European Radiology - Category: Radiology Source Type: research