Regulation of FGF23 Production in Osteocytes

AbstractPurpose of ReviewFGF23 is a bone-derived hormone working to reduce serum phosphate level. This review focuses on recent findings regarding regulatory mechanisms ofFGF23 expression in osteocytes, FGF23 levels, and activities.Recent FindingsCirculatory FGF23 levels reflecting FGF23 biological activities can be regulated by bothFGF23 expression and posttranslational modification of FGF23 protein. O-linked glycosylation and phosphorylation of FGF23 protein as well as enzymes that can cleave FGF23 protein are involved in the posttranslational modification. However, precise mechanisms of FGF23 protein processing are not clear. Several extracellular factors have been shown to affect FGF23 levels in kidney injuries. Contribution of these factors may be different depending on the causes and stages of kidney injury.SummaryFGF23 activities are regulated by complex mechanisms involving transcriptional and posttranslational modulations. There still remain several questions regarding the regulatory mechanisms ofFGF23 expression and FGF23 processing.
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research