Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer

Nature Reviews Urology, Published online: 05 February 2024; doi:10.1038/s41585-024-00859-xIn the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder cancer (NMIBC). No difference versus placebo was observed in recurrence-free interval (RFI) with selenium, but vitamin E was associated with worse RFI. Selenium and vitamin E cannot be recommended in chemoprevention for NMIBC. Furthermore, patients with NMIBC taking supplemental vitamin E should be made aware of its potential association with worse RFI.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research