Using a fluorescent enzyme-linked immunoassay as the first-line screening test for celiac disease obviates testing serum IgA levels and provides cost savings

Selective IgA deficiency (sIgAD - serum IgA 4years old), the most common inborn error of immunity (IEI), is 10-15 times more common in celiac disease (CD). Qatar has high prevalence of IEI and type 1 diabetes, the latter associated with CD. Our pre-existing CD protocol included serum IgA, tissue transglutaminase (tTG - IgA, IgG isotypes), endomysial antibodies (EMA) on all patients. It is reported that the IgA-tTG-IgA Celikey enzyme-linked immunoassay (ELiA) can detect IgA deficiency.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research