Seroconversion to 23 Valent Pneumococcal Polysaccharide Vaccination in Children with Type 1 Diabetes

People with diabetes are at higher risk of severe pneumococcal infections, and half of school-age children with Type 1 Diabetes Mellitus (T1DM) are colonized with Streptococcus pneumoniae, with reduced antibody response to T-cell dependent antigens suspected.1-5 23 Valent Pneumococcal Polysaccharide Vaccine (PPSV23) is recommended for children with T1DM, yet the response to vaccination is not well-characterized.6 We hypothesized that children with T1DM would have suboptimal immunological response to PPSV23 as assessed by IgG change, with lower age of patient and poor glycemic control associated with impaired response.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research