Role of 18F-FDG PET/CT for predicting bone marrow involvement, disease relapse and histopathological transformation in follicular lymphoma —a single centre observation

The objective of present study is to assess the role of the [18Fluorine] 2-Fluoro-2-Deoxy-D-Glucose Positron-Emission-Tomography Computed-Tomography (18F-FDG PET/CT) scan to detect the bone marrow involvement, predict disease free interval (DFI) and histopathological Transformation (HT) in Follicular Lymphoma (FL). Sixty patients were evaluated. Staging18F-FDG PET/CT scan showed poor sensitivity for bone marrow involvement. Thus, staging18F-FDG PET/CT cannot replace initial bone marrow biopsy in FL. Maximum standardized uptake value (SUVmax) of lymphomatous lesions in staging18F-FDG PET/CT scan has no correlation with DFI and HT. Treatment response based on 5-point Deauville Score (5PDS) of interim18F-FDG PET/CT scan is significantly associated with DFI. Interim18F-FDG PET/CT scan plays an important role in deciding treatment modification in FL to prevent future recurrence.
Source: Journal of Radioanalytical and Nuclear Chemistry - Category: Nuclear Medicine Source Type: research