Effect of albumin substitution on pharmacokinetics of piperacillin/tazobactam in patients with severe burn injury admitted to the ICU

ConclusionsAlbumin supplementation had little impact on the PK of piperacillin/tazobactam. After albumin supplementation, there was a numerical increase in mean AUC0 –8 of total and unbound piperacillin/tazobactam, whereas similarCmax values were observed. Future studies may investigate the effect of albumin supplementation on drugs with a higher plasma protein binding.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research