Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease

Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present in the kidney and increases with age and c...

Source: Genome Biology - January 29, 2024 Category: Genetics & Stem Cells Authors: Parker C. Wilson, Amit Verma, Yasuhiro Yoshimura, Yoshiharu Muto, Haikuo Li, Nicole P. Malvin, Eryn E. Dixon and Benjamin D. Humphreys Tags: Research Source Type: research