Novel mitophagy inducer alleviates lupus nephritis by reducing myeloid cell activation and autoantigen presentation.

Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), but its mechanism of onset remains unclear. Since impaired mitophagy has been implicated in multiple organs in SLE, we hypothesized that mitophagy dysfunction is critical in the development of LN and that pharmacologically targeting mitophagy would ameliorate this disease. Therefore, lupus-prone MRL/MpJ-Faslpr (MRL/lpr) and NZBWF1/J mice were treated with a novel mitophagy inducer, UMI-77, during their onset of LN.

Source: Kidney International - January 29, 2024 Category: Urology & Nephrology Authors: Huijing Wang, Mingdi Shen, Yanhong Ma, Lan Lan, Xue Jiang, Xufeng Cen, Gangqiang Guo, Qin Zhou, Mengmeng Yuan, Jianghua Chen, Hongguang Xia, Liang Xiao, Fei Han Tags: basic research Source Type: research