Genes, Vol. 15, Pages 173: Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation
Genes, Vol. 15, Pages 173: Extra Virgin Olive Oil Phenolic Compounds Modulate the Gene Expression of Biomarkers Involved in Fibroblast Proliferation and Differentiation
Genes doi: 10.3390/genes15020173
Authors:
Anabel González-Acedo
Rebeca Illescas-Montes
Elvira de Luna-Bertos
Concepción Ruiz
Javier Ramos-Torrecillas
Olga García-Martínez
Lucía Melguizo-Rodríguez
Extra virgin olive oil phenolic compounds have been identified as possible biostimulant agents against different pathological processes, including alterations in healing processes. However, there is little evidence on the molecular mechanisms involved in this process. The aim was to analyse the effect of hydroxytyrosol, tyrosol, and oleocanthal on fibroblast gene expression. PCR was used to determine the expression of different differentiation markers, extracellular matrix elements, and growth factors in cultured human fibroblasts CCD-1064Sk treated with different doses of hydroxytyrosol (10−5 M and 10−6 M), tyrosol (10−5 M and 10−6 M), and oleocanthal (10−6 M and 10−7 M). After 24 h of hydroxytyrosol treatment, increased expression of connective tissue growth factor, fibroblast growth factor (FGF), platelet-derived growth factor, vascular endothelial growth factor, transforming growth factor β1 (TGF-β1), and their receptors was observed. Tyrosol and olecanthal modulated the expressio...
Source: Genes - Category: Genetics & Stem Cells Authors: Anabel Gonz ález-Acedo Rebeca Illescas-Montes Elvira de Luna-Bertos Concepci ón Ruiz Javier Ramos-Torrecillas Olga Garc ía-Martínez Luc ía Melguizo-Rodríguez Tags: Article Source Type: research