Inhibition of repulsive guidance molecule-a ameliorates compromised blood –spinal cord barrier integrity associated with neuromyelitis optica in rats

We examined whether prophylactic intravenous administration of anti-repulsive guidance molecule-a antibodies (RGMa-Abs) has disease-modifying effects on BSCB dysfunction using an NMO model el icited by peripheral administration of AQP4-Abs to rats. RGMa-Ab treatment attenuated the acute exacerbation of perivascular astrocytopathy in the spinal cord and clinical symptoms, which were highly correlated with neurofilament light chain levels in both the cerebrospinal fluid (CSF) and serum.

Source: Journal of Neuroimmunology - January 27, 2024 Category: Allergy & Immunology Authors: Masataka Katsu, Misuzu Sekine, Masaharu Tanaka, Yasushi Horai, Airi Akatsuka, Misao Suga, Kazuhiro Kiyohara, Takuya Fujita, Atsushi Sasaki, Toshihide Yamashita Source Type: research