Whether full ‐length IL‐38 acts as a promoter or inhibitor in activating rheumatoid arthritis fibroblast‐like synoviocytes depends on IL‐1β

ConclusionFull-length IL-38 activates FLS functions and acts as a promoter in RA, whereas it inhibits FLS functions and acts as an inhibitor of RA in the presence of IL-1 β. The function of full-length IL-38 can be blocked by IL-1Ra and IL-36Ra.

Source: International Journal of Rheumatic Diseases - January 24, 2024 Category: Rheumatology Authors: Yudan Ding, Ju Shao, Cai Liu, Zhengtong Li, Yuping Zhang, Ligang Jie, Xiaotong Zhu, Bibo Liang, Qinghong Yu, Jing Wu Tags: ORIGINAL ARTICLE Source Type: research