Insulin sensitivity and beta cell function after Duodenal Mucosal Resurfacing (DMR): An Open-Label, Mechanistic, Pilot Study

The duodenum has been shown to play a key role in glucose homeostasis. Duodenal mucosal resurfacing (DMR) is an endoscopic procedure for patients with type 2 diabetes (T2D) in which the duodenal mucosa is hydrothermally ablated. DMR improves glycemic control, but the underlying mechanisms remain unclear. Here, we report changes in glucoregulatory hormones and indices of insulin sensitivity and beta cell function after DMR.

Source: Gastrointestinal Endoscopy - January 24, 2024 Category: Gastroenterology Authors: Celine B.E. Busch, Suzanne Meiring, Annieke C.G. van Baar, Amalia Gastaldelli, Ralph DeFronzo, Geltrude Mingrone, Moira Hagen, Kelly White, Harith Rajagopalan, Max Nieuwdorp, Jacques J.G.H.M. Bergman Source Type: research