Oxidative stress suppresses PHB2 ‐mediated mitophagy in β‐cells via the Nrf2/PHB2 pathway

ConclusionOur study suggested that PHB2-mediated mitophagy can protect β-cells from apoptosisvia the Nrf2/PHB2 pathway under oxidative stress. Antioxidants may protect β-cell from oxidative stress by prompting PHB2-mediated mitophagy. PHB2-mediated mitophagy as a potential mechanism takes part in the oxidative stress induced β-cell injury.

Source: Journal of Diabetes Investigation - January 24, 2024 Category: Endocrinology Authors: Shan Liu, Rui Zhang, Lan Zhang, Aige Yang, Yuqing Guo, Lei Jiang, Huijuan Wang, Shunjiang Xu, Huimin Zhou Tags: Original Article Source Type: research