Synthesis of 6,8-diaminopurines via Acid-induced Cascade Cyclization of 5-Aminoimidazole Precursors and Preliminary Anticancer Evaluation

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB01985C, PaperN ádia R. Senhorães, Bruna F. Silva, Raquel Sousa, Bruna P. Leite, Jorge M. Gonçalves, Filipe Alexandre Almeida Paz, Cristina Pereira-Wilson, Alice Dias Inspired by the pharmacological interest of 6-substituted purine roscovitine for cancer treatment, 5-aminoimidazole-4-carboxamidine precursors containing a cyanamide unit were prepared by condensation of 5-amino-4-cyanoformimidoylimidazoles with a wide range of primary... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research