Synthesis of 4-(Trichloromethyl)pyrido[2',1':3,4]pyrazino[2,1-b]quinazolinones through a Cyclized Dearomatization and Tri-chloromethylation Cascade Strategy

Org. Biomol. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3OB02084C, CommunicationXu Zhang, Meng-Yan Wei, Jun-Cheng Su, Cui Liang, Chengxue Pan, Gui-Fa Su, Dong-Liang Mo A variety of 4-(trichloromethyl)pyrido[2',1':3,4]pyrazino[2,1-b]quinazolinones were prepared in moderate to good yields with high regioselectivity through intramolecular 6-endo-dig cyclization and trichloromethylation of N3-alkynyl-2-pyridinyl tethered quinazolinones in chloroform. Mechanistic studies revealed that... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research