Organoid-guided Precision Hepatology for Metabolic Liver Disease

Metabolic dysfunction associated steatotic liver disease affects millions of people worldwide. Progress towards a definitive cure has been incremental and limited to only lifestyle modification. Hepatocyte-specific lipid accumulation is the main trigger of lipotoxic events, driving inflammafibrotic processes. The underlying pathology is extraordinarily heterogenous, and steatohepatitis manifestations are markedly influenced by metabolic communications across non-hepatic organs. Synthetic human tissue models have emerged as powerful platforms to better capture the mechanistic diversity in disease progression, while preserving individual-specific genetic traits.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research