Physiopathologic bases of Moebius Syndrome: combining genetic, vascular, and teratogenic theories.

Moebius Syndrome (MBS) is a Congenital Cranial Dysinnervation Disorder (CCDD) characterized by a bilateral palsy of abducens and facial cranial nerves, which may coexist with other cranial nerves palsies, mostly those found in the dorsal pons and medulla oblongata. MBS is considered a ‘rare’ disease, occurring in only 1:50,000 to 1:500,000 live births, with no gender predominance. Three independent theories have been described to define its etiology: the vascular theory talks about a transient blood flow disruption; the genetic theory, which takes place due to mutations relat ed to the facial motor nucleus neurodevelopment; and lastly, the teratogenic theory, associated with the consumption of agents such as misoprostol during the first trimester of pregnancy.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research