Distant neuroinflammation acutely induced by focal brain injury and its control by endocannabinoid system

CONCLUSION: The findings show that focal brain injury rapidly triggers widespread parenchymal and extraparenchymal neuroinflammation. The early injury-induced response is likely to represent neurogenic neuroinflammation produced by network hyperexcitability (acute symptomatic seizures). Activation of eCB signaling during acute phase of the brain injury is important for initiation of adaptive anti-inflammatory processes and prevention of chronic pathologic neuroinflammation in distant uninjured structures. However, the beneficial role of injury-induced eCB activity appears to depend on many factors including time, brain region, eCB tone etc.PMID:38190933 | DOI:10.1016/j.expneurol.2024.114679

Source: Experimental Neurology - January 8, 2024 Category: Neurology Authors: Anna A Karan Yulia S Spivak Elena M Suleymanova Konstantin A Gerasimov Alex P Bolshakov Lyudmila V Vinogradova Source Type: research