Paradoxical GH increase after oral glucose load in subjects with and without acromegaly

ConclusionsGH-Par response may be defined as a 20% increase in the first 90  min after glucose challenge. GH-Par, common in acromegaly and associated with an increased prevalence of glucose metabolism abnormalities, is found also in a subset of non-acromegalic subjects with high IGF-1 levels, suggesting its possible involvement in the early phase of the disease.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research