< em > olf413 < /em > , a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in < em > Drosophila melanogaster < /em >

J Genet. 2023;102:52.ABSTRACTOlf413 gene annotated as CG12673 in the genome of Drosophila melanogaster has been predicted to code for a protein with putative function in octopamine biosynthesis. The expression pattern and the biological function of the gene awaits investigation. The present study is the first report where we describe its expression in the late pupal brain as depicted by enhancer-driven green fluorescent protein (GFP) expression. With experiments using loss of function olf413 mutant flies, we have demonstrated that olf413 function is essential for motor activity, gravity sensing and spatial balancing of the body against gravity during climbing.PMID:38073169

Source: Journal of Genetics - December 11, 2023 Category: Genetics & Stem Cells Authors: Ravindrakumar Ramya Venkatanarayanasetty Baragur Shyamala Source Type: research