Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease

DISCUSSION rpAD constitutes an extreme subtype of AD with distinct features. GWAS found previously known and novel loci associated with rpAD. Highlights Rapidly progressive Alzheimer's disease (rpAD) was defined with different criteria. Whole genome sequencing identified rare missense variants in rpAD. Novel variants were identified for clinical rpAD on chromosome 21.PMID:38184787 | DOI:10.1002/alz.13655

Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Ping Wang Audrey Lynn Kristy Miskimen Yeunjoo E Song Thomas Wisniewski Mark Cohen Brian S Appleby Jiri G Safar Jonathan L Haines Source Type: research