Axial assembly of AuNR for tumor theranostics via Zn < sup > 2+ < /sup > -GSH chelation induced degradation of AuNR@ZIF-8 heterostructures

Colloids Surf B Biointerfaces. 2023 Dec 12;234:113706. doi: 10.1016/j.colsurfb.2023.113706. Online ahead of print.ABSTRACTTumor microenvironment responsive photothermal ablation is a noninvasive and accurately targeted approach for cancer therapy. Herein, an intracellular directional assembly strategy for enhanced photothermal therapy (PTT) was realized by using ZIF-8 encapsulated Au nanorod (AuNR) heterostructure as the precursor of photothermal convertible material. The ZIF-8 shell selectively degraded in tumor cells upon the chelation between GSH and Zn2+, while the as-formed Zn(SG) connected the released AuNR in end-to-end fashion. The coating of ZIF-8 shell significantly improves the stability and targeting of AuNR, and the released Zn2+ shielded the GSH binding site on the lateral side of AuNR, increased the plasmonic coupling efficiency of AuNR assembly geometer. This design enabled atomic-economical, efficient and low-side effect targeted photothermal therapy through the effective integration of heterostructures.PMID:38176334 | DOI:10.1016/j.colsurfb.2023.113706
Source: Colloids and Surfaces - Category: Biotechnology Authors: Source Type: research