Epigenetic control of adamantinomatous craniopharyngiomas

CONCLUSION: Two clusters of ACP patients were consistently revealed by unsupervised machine learning methods, being one of them significantly hypomethylated, enriched by CTNNB1 mutated ACPs, and associated with increased tumor size. Enrichment analysis reinforced pathways involved in tumor proliferation and in cell-specific tumoral microenvironment.PMID:38181427 | DOI:10.1210/clinem/dgae006

Source: The Journal of Clinical Endocrinology and Metabolism - January 5, 2024 Category: Endocrinology Authors: Junier Marrero-Guti érrez Ana Carolina Bueno Clarissa Silva Martins Fernanda Borchers Coeli-Lacchini Rui M Patr ício Silva-Júnior Gabriel Henrique Marques Gon çalves Jorge Guilherme Okanobo Ozaki Danillo C de Almeida E Silva Luiz Eduardo Wildemberg Xi Source Type: research