Secreted insulin-like growth factor binding protein 5 functions as a tumor suppressor and chemosensitizer through inhibiting insulin-like growth factor 1 receptor/protein kinase B pathway in acute myeloid leukemia

CONCLUSIONS: Our findings revealed secreted rather than intracellular IGFBP5 as a tumor-suppressor and chemosensitizer in AML. Upregulation of serum IGFBP5 by overexpression or addition of extrinsic rhIGFBP5 may serve as a suitable therapeutic approach for AML.PMID:38159363 | DOI:10.1016/j.neo.2023.100952

Source: Neoplasia - December 30, 2023 Category: Cancer & Oncology Authors: Beiying Zhang Xiaoling Deng Ruolan You Jingru Liu Diyu Hou Xiaoting Wang Shucheng Chen Dongliang Li Qiang Fu Jingdong Zhang Huifang Huang Xiaoli Chen Source Type: research