Subcutaneous Anti-inflammatory Therapies to Prevent Burn Progression in  a Swine Model of Contact Burn Injury

CONCLUSIONS: This report employs an established model of porcine contact burn injury in order to test the ability of local subcutaneous delivery of therapeutics to prevent burn progression at the point of injury, via what is believed to be the inhibition of inflammation. Several treatments successfully prevented burn progression to a full-thickness injury, potentially improving wound healing outcomes in a simulated battlefield scenario. Subcutaneously administered therapies combating burn-induced inflammation at the point of injury may serve as a field-deployable treatment modality to improve warfighter recovery and return to duty.PMID:38150385 | DOI:10.1093/milmed/usad476

Source: Military Medicine - December 27, 2023 Category: International Medicine & Public Health Authors: Marc A Thompson Lucy Shaffer David A Larson Michelle Stavena-Holik Carole Nail Logan Leatherman Seth Tomblyn Luke Burnett Julie Rizzo Robert J Christy Christine J Kowalczewski Source Type: research