Prognostic Value of Ultra-Low-Pass Whole-Genome Sequencing of Circulating Tumor DNA in hepatocellular carcinoma under systemic treatment

CONCLUSIONS: ULP-WGS of cfDNA provides clinically relevant information about the tumor biology. The presence of ctDNA and the loss of 5q and 16q arms in ctDNA-positive patients are independent predictors of worse prognosis in patients with advanced HCC under systemic therapy.PMID:38163441 | DOI:10.3350/cmh.2023.0426

Source: Clinical and molecular hepatology - January 1, 2024 Category: Gastroenterology Authors: Miguel Sogbe Idoia Bilbao Francesco P Marchese Jon Zazpe Annarosaria De Vito Marta Pozuelo Delia D'Avola Mercedes I ñarrairaegui Carmen Berasain Maria Arechederra Josepmaria Argemi Bruno Sangro Source Type: research