In search of critical dsRNA targets of ADAR1

Trends Genet. 2023 Dec 29:S0168-9525(23)00261-5. doi: 10.1016/j.tig.2023.12.002. Online ahead of print.ABSTRACTRecent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.PMID:38160061 | DOI:10.1016/j.tig.2023.12.002
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Source Type: research