Features of immunometabolic depression as predictors of antidepressant treatment outcomes: pooled analysis of four clinical trials

CONCLUSIONS: Depressive symptoms of people with more IMD features improved less when treated with antidepressants. However, clinical relevance is limited owing to small effect sizes in inconsistent associations. Whether these patients would benefit more from treatments targeting immunometabolic pathways remains to be investigated.PMID:38130122 | DOI:10.1192/bjp.2023.148

Source: The British Journal of Psychiatry for Mental Science - December 22, 2023 Category: Psychiatry Authors: Sarah R Vreijling Cherise R Chin Fatt Leanne M Williams Alan F Schatzberg Tim Usherwood Charles B Nemeroff A John Rush Rudolf Uher Katherine J Aitchison Ole K öhler-Forsberg Marcella Rietschel Madhukar H Trivedi Manish K Jha Brenda W J H Penninx Aartjan Source Type: research