6 ‐Nitrodopamine is an endogenous mediator of the rabbit corpus cavernosum relaxation

Discussion and conclusion6-Nitrodopamine is the most potent endogenous relaxant agent in RbCC ever described and represents a novel mechanism by which NO causes corpus cavernosum smooth muscle relaxation. The finding that 6-ND acts as a truly selective dopamine D2-receptor antagonist indicates that the balance of dopamine and 6-ND release/synthesis may be the main mechanism that modulates corpus cavernosum smooth muscle tonus in vivo.

Source: Andrology - December 30, 2023 Category: Urology & Nephrology Authors: Antonio Tiago Lima, Jos é Britto‐Júnior, Manoel Odorico Moraes, Maria Elisabete A. Moraes, Adriano Fregonesi, Fabíola Z. Monica, Edson Antunes, Gilberto De Nucci Tags: ORIGINAL ARTICLE Source Type: research