A comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations

This study is the first comprehensive urinary omics analysis focusing on renal AA Amyloidosis to the best of our knowledge. Based on physiologic roles and clinicopathologic correlations of the molecules; UMOD, AMBP and myo-inositol were related with tubulointerstitial damage, whereas RNase1 and urate were believed to be increased with systemic inflammation and endothelial damage in AA amyloidosis.PMID:38154551 | DOI:10.1016/j.jprot.2023.105064

Source: Journal of Proteomics - December 28, 2023 Category: Biochemistry Authors: Deniz Aral Ozbek Sila Cankurtaran Koc Nazli Ezgi Ozkan Ku çuk Sevilay Erdogan Kablan Idil Yet Meral Uner Nurhan Ozlu Emirhan Nemutlu Incilay Lay Arzu Saglam Ayhan Tolga Yildirim Mustafa Arici Seref Rahmi Yilmaz Yunus Erdem Bulent Altun Source Type: research