G-CSF induced hematopoietic stem cell mobilization from the embryonic hematopoietic niche does not require neutrophils and macrophages

Granulocyte colony-stimulating factor (G-CSF) induces the production of mature neutrophils, promotes the proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs), and facilitates the release of HSPCs from the bone marrow1,2. Its capability to release HSPCs has made G-CSF one of the pioneering cytokines used for HSPC mobilization, a process involving the release of HSPCs from the bone marrow to collect them from the peripheral blood during stem cell transplantation. To date, G-CSF remains the most widely employed mobilizing agent and can be combined with other drugs or cytokines, such as AMD3100 or GRO β, to enhance mobilization efficiency3–5.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research