Physicochemical Features and Applicability of Newly Fabricated Phytopharmaceutical-Loaded Hydrogel Alginate Microcarriers with Viscoelastic Polyelectrolyte Coatings

Chemphyschem. 2023 Dec 20:e202300758. doi: 10.1002/cphc.202300758. Online ahead of print.ABSTRACTThe design of novel polymeric carrier systems with functional coatings is of great interest for delivering various bioactive molecules. Microcapsules coated with polyelectrolyte films provide additional functionality and fine-tuning advantages essential for controlled drug release. We developed hydrogel microcarriers coated with functional polyelectrolyte films with encapsulated substances of natural origin, resveratrol, curcumin, and epigallocatechin gallate, which have cytotoxic and chemopreventive properties. Alginate based microparticles were loaded with phytopharmaceuticals using the emulsification method and then their surface was modified with PE coatings, such as chitosan or poly(allylamine hydrochloride). The morphology and mean diameter of microcarriers were characterised by scanning electron microscopy, encapsulation efficiency was determined by UV-Vis spectroscopy whereas the physicochemical properties of functional PE layers were studied using quartz crystal microbalance with dissipation monitoring. The release profiles of active compounds from the hydrogel microparticles were described using the Peppas-Sahlin model. The cytotoxic effect of designed delivery systems was studied by evaluating their impact on the proliferation, mitochondrial metabolic function, and lipid peroxidation level of 5637 human bladder cancer cells. Our work demonstrates that the physicochemica...
Source: Chemphyschem - Category: Chemistry Authors: Source Type: research