Comprehensive Multiomics Analysis of Monozygotic Twin Discordant for Double Outlet Right Ventricle

This study demonstrates a multiomics profile of discordant twins and explores the possible mechanism of DORV development. Global hypomethylation might be associated with the risk of CHDs. Specific genes and specific pathways, particularly those involving ECM-receptor interaction, focal adhesion and TGF-β signaling, might be involved in the occurrence of CHDs.PMID:38099413 | DOI:10.1017/thg.2023.51

Source: Twin Research and Human Genetics - December 15, 2023 Category: Genetics & Stem Cells Authors: Zhen Liu Nana Li Xiaoyu Pan Jun Li Shengli Li Qintong Li Ping Li Ying Deng Fang Chen Hui Jiang Wei Wang Dezhi Mu Ping Yu Jun Zhu Source Type: research