Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO < sub > 2 < /sub > nanoparticles using Psidium guajava  leaf extract with enhanced antimicrobial and anticancer activities

This study focuses on the synthesis of titanium oxide (TiO2) and dopamine (DA) carboxymethyl cellulose (CMC)-doped TiO2 (DA/CMC/TiO2) NP using Psidium guajava leaf extract, while also investigating the structural, optical, and morphological and biocidal potential of the prepared NPs. Significantly larger zones of inhibition were observed for DA/CMC/TiO2 NPs compared to TiO2 against various pathogens. Moreover, the MTT assay was carried out to evaluate the anticancer activity of the prepared samples against MG-63 cells, and the results revealed that DA/CMC/TiO2 NPs exhibited significantly higher level of anticancer activity compared to TiO2. The experimental results demonstrated that DA/CMC/TiO2 NPs exhibited enhanced anticancer activity in a dose-dependent manner when compared to TiO2 NPs.PMID:38103080 | DOI:10.1007/s00449-023-02954-6
Source: Bioprocess and Biosystems Engineering - Category: Biomedical Engineering Authors: Source Type: research