Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats

In conclusion, rPSAP attenuated neuronal apoptosis and improved neurological function through GPR37/PI3K/Akt/ASK1 pathway after MCAO in rats. Therefore, further exploration of PSAP as a potential treatment option in ischemic stroke is warranted.PMID:38114054 | DOI:10.1016/j.expneurol.2023.114656

Source: Experimental Neurology - December 19, 2023 Category: Neurology Authors: Jing Yu Jinlan Li Nathanael Matei Wenna Wang Lihui Tang Jinwei Pang Xue Li Lili Fang Jiping Tang John H Zhang Min Yan Source Type: research