HIIT Induces Stronger Shifts within the Peripheral T Cell Compartment Independent of Sex
Int J Sports Med DOI: 10.1055/a-2197-0882Acute exercise induces changes within the T-cell compartment, especially in
cytotoxic CD8+ memory subsets, depending on exercise
intensity and duration. It is unclear whether exercise-induced changes in major
T-cell subsets differ in response to acute high-intensity interval training
(HIIT) or moderate-intensity continuous training (MICT) and whether sex-specific
effects exist. Twenty-four recreationally active runners (females: n=12,
27.8±4.1years,
54.4±4.6 ml*kg-1*min-1;
males: n=12, 31.6±3.8years,
58.9±7.7 ml*kg-1*min-1)
participated in this randomized controlled crossover study, and conducted an
energy- and duration-matched HIIT and MICT session. Blood was sampled before
(T1), immediately (T2) and 1 h after exercise
(T3). Flow cytometry was used to identify T-cell populations.
HIIT decreased the proportion of CD8+ T-cells more
pronounced at T3 compared to MICT (p=0.007), induced a
significantly stronger increase in the CD8+ effector
memory (TEM) cell proportion at T2 (p=0.032), and
decreased CD4+ central memory proportion more
pronounced at T2 (p=0.029). A decrease below baseline
CD8+ TEM proportion at T3
was observed only after HIIT (p<0.001). No interaction effects between
sexes we...
Source: International Journal of Sports Medicine - Category: Sports Medicine Authors: Proschinger, Sebastian Schenk, Alexander Metcalfe, Alan J. Zimmer, Philipp Tags: Physiology & Biochemistry Source Type: research
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