Phenolic constituents with antibacterial activity from Eleutherine bulbosa

Fitoterapia. 2023 Dec 18:105787. doi: 10.1016/j.fitote.2023.105787. Online ahead of print.ABSTRACTEleutherine bulbosa (Mill.) Urb. is a medicinal and edible plant with various benefits for humans and animals. In this work, four new phenolic constituents (1-4), along with six known phenolic compounds (5-10) were obtained from the red bulbs of E. bulbosa. Their structures with absolute configurations were characterized by extensive spectroscopic analysis, combined with HR-ESI-MS and quantum mechanical electronic circular dichroism (ECD). Compounds 1 and 2 are novel homologous and heterodimers, respectively, featuring an unusual spiro ring system. All isolated phenolic constituents were tested for their antibacterial effects. The results revealed four phenolic compounds 1-3 and 7 showed moderate antibacterial activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli with minimum inhibitory concentration (MIC) values ranging from 15.6 to 250.0 μg/mL.PMID:38122855 | DOI:10.1016/j.fitote.2023.105787
Source: Fitoterapia - Category: Biochemistry Authors: Source Type: research