Physician- and patient-reported dermatologic comorbidities of hypermobile Ehlers-Danlos syndrome

To the Editor: Despite hypermobile Ehlers-Danlos syndrome (hEDS) being the most common inherited connective tissue disorder, it remains the only Ehlers-Danlos syndrome (EDS) subtype without a known causative gene.1 It is hypothesized that altered dermal mechanics from suspected collagenopathy and aberrant mast cell activation predispose hEDS to cutaneous disease, and historically known cutaneous afflictions include mast cell activation disorder spectrum and chronic spontaneous urticaria, abnormal scars or wound healing, piezogenic papules, dyshidrosis, extensible or soft skin, easy bruising, local anesthesia resistance, keratosis pilaris, striae, and hidradenitis suppurativa.

Source: Journal of the American Academy of Dermatology - November 28, 2023 Category: Dermatology Authors: Alan N. Snyder, Almeera Lateef, Nicholas Strat, Laura Andrews, Chelsea Shope, Cortney Gensemer, Bao Xin Liang, Taylor Petrucci, Mark Lavallee, Russel Norris, Dirk Elston Tags: Research letter Source Type: research