Non-lesional white matter changes depicted by q-space diffusional MRI correlate with clinical disabilities in multiple sclerosis

We previously developed an optimized q-space diffusional MRI technique (normalized leptokurtic diffusion [NLD] map) to delineate the demyelinated lesions of multiple sclerosis (MS) patients. Herein, we evaluated the utility of NLD maps to discern the white matter abnormalities in normal-appearing white matter (NAWM) and the abnormalities' possible associations with physical and cognitive disabilities in MS.

Source: Journal of the Neurological Sciences - December 19, 2023 Category: Neurology Authors: Haruhiko Motegi, Kenji Kufukihara, Satoshi Kitagawa, Koji Sekiguchi, Junichi Hata, Hirokazu Fujiwara, Masahiro Jinzaki, Hideyuki Okano, Masaya Nakamura, Yasuyuki Iguchi, Jin Nakahara Source Type: research