Roles of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor 2 in Endotoxin-Induced Acute Retinal Inflammation

CONCLUSION: SphK1/S1P/S1PR2 signaling was upregulated in EIU and S1PR2 inhibition suppressed inflammatory response. Targeting this signaling pathway has potential for treating retinal inflammatory diseases.PMID:38100527 | DOI:10.1080/09273948.2023.2273963

Source: Ocular Immunology and Inflammation - December 15, 2023 Category: Allergy & Immunology Authors: Tazbir Ahmed Takafumi Suzuki Ryo Terao Reiko Yamagishi Ryosuke Fujino Kunihiro Azuma Hirotsugu Soga Takashi Ueta Megumi Honjo Sumiko Watanabe Kazuaki Yoshioka Yoh Takuwa Makoto Aihara Source Type: research