Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments

AbstractPyrrolobenzodiazepines (PBDs) are a potent class of compounds that have been analyzed since the 1960s and are found naturally in a wide variety of species. They may be obtained through extraction from natural sources or through synthetic routes. A variety of studies have indicated remarkable anti-tumor, anti-bacterial, analgesic, and anti-neurodegenerative activities of PBDs. This review will examine natural sources of PBDs, their biological activities, newer synthesis strategies, and the effect of structural modifications, specifically from a neurological standpoint. Emerging studies on pyrrolobenzodiazepines offer encouragement for further research on their neurological activities potentially leading to therapeutic uses in addition to that as an oncological agent.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research